The Experimental Neuroscience working group is committed to expanding scientific knowledge in the field of neuronal functions under physiological and pathological conditions. It focuses on research into the cellular and molecular biology of synaptic transmission and plasticity, neuronal development and signaling, inflammation of the nervous system, physiology of receptors and ion channels, homeostatic and metabolic processes. The group also deals with the issue of neurodegenerative diseases (epilepsy, AD, PD, cerebral ischemia, etc.) both in adulthood and during the perinatal period.

The department uses a range of methods and tools, including immunofluorescence imaging, biochemistry, in vivo photometry, electrophysiology, microdialysis and molecular genetic approaches. Its goal is to define the connection between basic research in neurobiology, clinical neurology and psychiatry in the broadest sense of the word.

The working group maintains close ties with other NIMH research groups, the 3rd Faculty of Medicine of Charles University, the Institute of Physiology and the Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, and with international associates from the USA, Canada, Germany, Italy and others. The group is actively involved in Erasmus Plus exchange stays of foreign students.